formulation

Abstract A novel polymer synthesized by grafting three cyclodextrins onto chitosan was characterized and evaluated for its potential to adsorb two pharmaceutical residues: ibuprofen and progesterone. The influence of various operational parameters, including contact time, initial molecule…
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Abstract Microarray patches (MAPs) offer a noninvasive and patient-friendly drug delivery method, suitable for self-administration, which is especially promising for low- and middle-income country settings. This study focuses on the development of dissolving bilayer MAPs loaded with norelgestromin…
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ABSTRACT Introduction: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted…
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Compaction Blend M from MEGGLE Fast, Reliable, Efficient. The direct compressible ready-to-use powder mixture for all kinds of technical applications! When investing in new tableting equipment, ensuring a fast and efficient commissioning process is crucial. Introducing …
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Abstract Recently, transmucosal drug delivery systems (TDDSs) have been extensively studied because they protect therapeutic agents from degradation; improve drug residence time at the mucosal membranes; and facilitate sustained drug release for a prolonged period. Chitosan is a well-researched…
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Hot melt extrudates with combinations of Soluplus® and Aqoat® AS-L or Eudragit® EPO were investigated to improve drug release and to overcome the pH-dependent release of poorly water-soluble basic (itraconazole, ITZ) and acidic (mefenamic acid, MFA) drugs. The release of ITZ was improved in both 0.1…
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Introduction Pellets are versatile dosage forms for many actives. To control drug dissolution profiles, they can be prepared with different coatings. Coated multiparticulate systems are known to show less variation in drug release than single unit formulations. Furthermore, dose dumping effects due…
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Pulmonary delivery of antibiotics is an effective strategy in treating bacterial lung infection for cystic fibrosis patients, by achieving high local drug concentrations and reducing overall systemic exposure compared to systemic administration. However, the inherent anatomical lung defense…
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Abstract Background: Fenofibrate (FF) is a BCS class II compound whose poor solubility poses challenges in drug delivery and bioavailability. Solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged as a promising solution to address these issues. These systems are aimed at…
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Introduction We are Sigachi, a leading name in the world of Microcrystalline Cellulose (MCC) manufacturing tailored for Pharmaceutical applications. With a global footprint spanning over 50+ countries, Sigachi has been a trusted supplier for over three decades, earning a reputation among top…
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