formulation

Abstract Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules more efficiently to pathological sites and by attenuating their accumulation in healthy organs and tissues, nanomedicine formulations aim to improve the balance between drug efficacy and toxicity.…
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ABSTRACT Introduction 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact of 3DP in drug product development.…
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Learn the step-by-step process of gelatin production, from raw material preparation to the final product. This guide covers both the hot melt and cold melt methods, equipment needed, and common issues encountered in the manufacturing process. Production of Gelatin The production of gelatin for…
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Abstract None of transitional lipid-based drug delivery systems (LBDDS) includes compositions containing one lipid and one water-soluble surfactant that form stable microemulsions. The conversion of liquid LBDDS to solid LBDDS has been limited by low drug loading. Previously, we have developed…
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Tablet disintegration is crucial for drug release and subsequent systemic absorption. Although factors affecting the disintegrant’s functionality have been extensively studied, the impact of wet granulation on the performance of disintegrants in a poorly water-soluble matrix has received much less…
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OVERVIEW HOT MELT EXTRUSION (HME) Hot Melt Extrusion (HME) offers several advantages over traditional pharmaceutical processing techniques such as fewer processing steps, continuous operation, little or no solvents, and commercial scale production of solid dispersions with improved…
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Gelatin, a versatile protein derived from animal sources, is crucial in producing softgel capsules. Known for its ability to form gels in aqueous solutions, gelatin provides the perfect medium for encapsulating various substances. This comprehensive guide will explore the different aspects of…
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Adequate stabilization is essential for marketed protein-based biopharmaceutical formulations to withstand the various stresses that can be exerted during the pre- and post-manufacturing processes. Therefore, a suitable choice of excipient is a significant step in the manufacturing of such delicate…
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Abstract Biopharmaceuticals are labile biomolecules that must be safeguarded to ensure the safety, quality, and efficacy of the product. Batch freeze-drying is an established means of manufacturing solid biopharmaceuticals but alternative technologies such as spray-drying may be more suitable for…
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Abstract Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and consequently biological activity. Interestingly several binary SD systems continue to exhibit insufficient solubility over time. Therefore, the goal of…
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