formulation

Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate repanglinide (RPG) nanosuspension-based buccal fast-dissolving films (BDFs) for dissolution enhancement. RPG nanosuspension was prepared by the…
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This study employed a Quality by Design (QbD) approach to spray dry amorphous clotrimazole nanosuspension (CLT-NS) consisting of Soluplus® and microcrystalline cellulose. Using the Box-Behnken Design, a systematic evaluation was conducted to analyze the impact of in let temperature, % aspiration,…
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Abstract Montelukast sodium is widely used in treatment of asthma and other allergic disorders. The Montelukast sodium is a water insoluble drug but need quick action. So we planned a mouth dissolving tablet of Montelukast sodium. Further we evaluated functionality of co-processed super…
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Abstract Drug delivery is essential to provide correct treatments in many ways. The critical points in any drug delivery method are patient compliance, maximum efficacy in therapy, minimum toxicity, and enabling new medical treatments. Pulmonary drug delivery is one way of delivering therapeutics…
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Real-time monitoring of critical quality attributes, such as residual water in granules after drying which can be determined through loss-on-drying (LOD), during wet granulation and drying is essential in continuous manufacturing. Near-infrared (NIR) spectroscopy has been widely used as process…
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Dwell time is an important parameter responsible for the material deformation and the mechanical and biopharmaceutical properties of the tablet. Thus, it is widely used for scale-up purposes. The geometric dwell time (GDT) can be assumed based on the shape of the punch head and the diameter and…
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Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the decreased viability and vitality of microorganisms. Thus, the excipients with increased plasticity can be considered as an option to decrease…
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This poster was presented at CRS 2024 in Bologna Purpose Nanomedicine has immense potential as it offers nanoparticle(NP)-based delivery vehicles for vaccines or APIs. Polymeric NPs have been used for drug delivery due to their biocompatibility, biodegradability and potential to provide customized…
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Producing soft gelatin capsules (softgels) involves meticulous attention to detail and a deep understanding of the materials and processes. In this article, we will delve into the critical aspects of fill material production, exploring techniques to ensure uniformity, the importance of equipment,…
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Abstract Aim: This study focused on developing a topical gel incorporating lornoxicam-loaded poly(lactic-co-glycolic acid) and polyethylene glycol (PLGA-PEG) blend nanoparticles to mitigate gastrointestinal (GIT) side effects and enhance therapeutic efficacy. Materials & methods: Synthesized…
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