pellets

Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim…
Read More...

Spherical pharmaceutical pellets are commonly produced by an extrusion-spheronization process. In the spheronizer, the wet cylindrical extrudates are rounded into spheres due to multiple collisions. In order to model this rounding, a suitable contact model, which can predict the dominantly…
Read More...

The direct pelletization process is a fast and flexible operation with the potential to produce high quality particles appropriate for sophisticated oral solid dose formulations where a narrow Particle Size Distribution (PSD) is required. Particle size is a critical quality attribute for many…
Read More...

In recent years, formulations based on pellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients and are therefore very popular with pharmaceutical customers. But which technologies are the most important? Download…
Read More...

The aim of this study was to evaluate how the addition of hydrophobic inclusions to sustained-release pellet film coat can affect drug release. Sustained-release formulations, in particular multiparticulate systems are gaining popularity because they are able to reduce the dosing frequency of drugs…
Read More...

The objective of this study was to investigate the effect of binder (water-soluble vs. -insoluble) and granulation fluid (aqueous vs. organic) on the physical properties of pellet prepared by extrusion/spheronization and on drug release. Size distribution, sphericity, bulk density, crushing force…
Read More...

Oral modied-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form…
Read More...

Drug layering on starter pellets is a standard technology to achieve multiparticulate dosage forms. The most widely used are still sugar spheres / non-pareils but also neutral pellets made of microcrystalline cellulose such as Cellets are applied. Although not a lot of new starter pellets have come…
Read More...