Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Tacrolimus Encapsulated Mesoporous Silica Nanoparticles Embedded Hydrogel for the Treatment of…
Atopic dermatitis (AD) is a repetitive inflammatory skin disorder with limited treatment options. Innovative targeted therapies are gaining significant interest and momentum towards disease control including better ways to deliver drugs topically. Tacrolimus is one such compound which is used to…
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SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from…
The value proposition for formulation scientists is:
A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
A texture optimal for patient compliance…
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Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually…
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Screening of Surfactants for Improved Delivery of Antimicrobials and Poly-Lactic-co-Glycolic Acid…
Topical wound management is often a challenge due to the poor penetration of antimicrobials in wound tissue and across the biofilm matrix where bacteria are embedded. Surfactants have been used for decades to improve the stability of formulations, increase drug solubility, and enhance penetration.…
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Polymeric microneedles for transdermal delivery of nanoparticles: Frontiers of formulation,…
With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes. Among the various types of MNs, polymeric microneedles (PMNs)…
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Topical nanocarriers for management of Rheumatoid Arthritis: A review
Rheumatoid arthritis (RA) is a systemic autoimmune disease manifested by chronic joint inflammation leading to severe disability and premature mortality. With a global prevalence of about 0.3%–1% RA is 3–5 times more prevalent in women than in men. There is no known cure for RA; the ultimate goal…
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Molecular Dynamics Simulations to Elucidate Translocation and Permeation of Active from Lipid…
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP). Nonetheless, molecular-level understanding into the mechanism of active delivery from NP to skin has scarcely been studied, compared to their…
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The Formulation Finder for Topicals module is now available in ZoomLab™
This new, interactive module addresses both chemical and patient compatibility concerns, guiding ZoomLab™ users to the most suitable base cream formulations.
Topical formulation development is a complex process that requires consideration of numerous factors. The ZoomLab™ Formulation Finder for…
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Topical Nanoemulgel for the Treatment of Skin Cancer: Proof-of-Technology
The present study is a mechanistic validation of ‘proof-of-technology’ for the effective topical delivery of chrysin nanoemulgel for localized, efficient treatment of melanoma-affected skin.
Background: Currently available treatments for skin cancer are inefficient due to systemic side effects…
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Efficacy of topical risedronate and risedronate – Eudragit E complex in a model of cutaneous…
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge. Systemic risedronate (Ris) has been reported to have anti-leishmanial properties and Eudragit EPO (EuE) has shown in vitro activity against L. (L.) amazonensis. The aim of this work…
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