Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization
This research aimed to develop a novel drug delivery system to improve treatment of skin disorders. The system is comprised of a Carbopol 980-based nanoemulgel (NE-gel) containing a desonide (DES; 0.05%, w/w) nanoemulsion (NE), which has a small particle size, high encapsulation efficiency,…
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Brucine-loaded transliposomes nanogel for topical delivery in skin cancer: statistical optimization,…
The aim of the present study was to develop, optimize brucine-loaded transliposomes (BRC-TL) formulation for dermal delivery of brucine for skin cancer. The BRC-TL formulations were evaluated for vesicle size, entrapment efficiency, and in vitro drug release. The optimized formulation was further…
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Formulation and Evaluation of Naproxen Emulgel for Topical Delivery
Topical conveyance of medications can be accomplished by fusing drug into the gel network for viable conveyance of medications. NSAIDs are non-steroidal medications having superb mitigating and pain-relieving action however NSAIDs produces GIT ulceration, liver and kidney inconvenience particularly…
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Delivering therapeutic cannabinoids via skin: Current state and future perspectives
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over…
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Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical…
The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized employing a 3-factor, 3-level Box-Behnken design. The effect of formulation…
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Tefose® 63 – A nonionic oil-in-water emulsifier for topical formulations
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a self-emulsifying base.
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Tefose® 63 is a non-ionic…
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Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In…
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier systems to enhance the bioavailability of drugs. This study investigated the prospects of drug-loaded SLNs to increase the ocular permeation and improve the therapeutic potential of clarithromycin in topical…
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Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile…
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed…
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Development, Pre-clinical Investigation and Histopathological Evaluation of Metronidazole Loaded…
Background: Metronidazole (MTZ) is an anti-oxidant and anti-inflammatory agent with beneficial therapeutic properties. The hydrophilic nature of the molecule limits its penetration across the skin. Existing commercial formulations have limitations of inadequate drug concentration present at the…
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Formulation and evaluation of transdermal nanogel for delivery of artemether
Artemether (ART) is second to artesunate in being the most widely used derivatives of artemisinin in combination therapy of malaria. Nanostructured lipid carrier (NLC) formulations were prepared following our previous report using optimized ART concentration of 0.25 g dissolved in 5% w/v mixture of…
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