Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Nanostructured lipidic carriers for dual drug delivery in the management of psoriasis: Systematic…
In the present study, we selected two potential herbal drugs (Smilax china and Salix alba) and developed nano lipidic carriers (NLC) gel for safe and effective topical therapy against psoriasis. Optimization of formulation of NLCs was performed using Box-Behnken design by selecting three input…
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Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate
Sodium alendronate is a nitrogen-containing bisphosphonate, widely used for osteoporosis treatment. However, due to its several oral administration drawbacks, the transdermal route represents an interesting option. The aim of this study was to formulate sodium alendronate in two submicron delivery…
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Ebselen nanoemulgel for the treatment of topical fungal infection
Superficial mycoses are the fungal infections of skin, hair and nail which affect thousands of people worldwide. Emerging resistance to azole antifungals is a common problem in the treatment of superficial or systemic fungal infection. Ebselen (EB), an organoselenium compound, has demonstrated…
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Development and Characterization of Water-in-Oil Microemulsion for Transdermal Delivery of Eperisone…
Background: Eperisone hydrochloride possesses short biological half-life due to first pass metabolism resulting in low bioavailability and short duration of response with toxic effects, ultimately limits its utilization for treatment of muscle spasm.
Objective: In view of this background, current…
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Nanoscale investigation of human skin and study of skin penetration of Janus nanoparticles
Janus nanoparticles (JNP) are innovative nanocarriers with an interesting pharmaceutical and cosmetic potential. They are characterized by the presence of a lipid compartment associated with an aqueous compartment delimited by a phospholipid bilayer containing phospholipids and non-ionic…
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Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of…
Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation. The structure and substitution degrees of these derivatives were confirmed by 1H NMR- and FTIR-spectroscopy. These derivatives are more hydrophobic compared to…
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Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification…
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Design, Optimization and Characterization of Nanostructured Lipid Carriers of Raloxifene…
Raloxifene Hydrochloride (RXL), a BCS class II drug, is used for the treatment of invasive breast cancer and osteoporosis in post menopausal women. Even though the drug is highly efficient, it shows poor bioavailability of 2% when administered orally. The aim of the study was to develop,…
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Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect…
The objective of the study was to assess the effect of enhanced mucoadhesion of a cationic mucoadhesive nanostructured lipid carrier (NLC) on its ocular disposition after topical administration. The NLC was made mucoadhesive by surface coating with chitosan oligosaccharide (COS), a low molecular…
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Formulation, optimization and in vitro evaluation of nanostructured lipid carriers for topical…
This work was aimed to formulate topical Apremilast loaded nanostructured lipid-carriers (NLCs) for the management of psoriasis.
Psoriasis is a widespread skin condition considered to be a Th1 autoimmune skin disease and characterized by excessive growth and abnormal differentiation of…
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