Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Montelukast Nanocrystals for Transdermal Delivery with Improved Chemical Stability
A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal delivery, while ensuring chemical stability of the labile compound.
MTK nanocrystal suspension was fabricated using acid-base neutralization and ultra-sonication technique and was characterized as follows:…
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Mechanistic Evaluation of Enhanced Curcumin Delivery through Human Skin In Vitro from Optimised…
Curcumin is a natural product with chemopreventive and other properties that are potentially useful in treating skin diseases, including psoriasis and melanoma.
However, because of the excellent barrier function of the stratum corneum and the relatively high lipophilicity of curcumin (log P 3.6),…
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Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic…
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly demonstrated.
CAR SDs were prepared using the solvent…
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Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose
Achieving drug delivery at the ocular level encounters many challenges and obstacles.
In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment of a wide range of ocular diseases. The present work…
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Polymeric microneedles for controlled transdermal drug delivery
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems because of their controlled drug delivery, tunable properties, and ease of patient self-administration.
They are biocompatible and can easily and painlessly penetrate the stratum corneum, delivering their…
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Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology
Oromucosal delivery of active pharmaceutical ingredients provides an attractive alternative route of administration, due to avoidance of the first pass effect and improved patient compliance. In the current work, fused deposition modelling (FDM) 3D printing was investigated as an additive…
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Say good-bye to greasy and sticky topical medicines: Solutions and inspirations for sensorial…
It is widely recognised that patient adherence to topical drugs is low because of the complexity or inconvenience of the treatment regimen1 (difficult self- application, number of applications, time consumption, etc.). This leads to poor treatment efficacy in relation to cost. Adherence has also…
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Review Topical Inserts: A Versatile Delivery Form for HIVPrevention
The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms.
They may be used for vaginal and/or rectal…
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Effect of permeation enhancers on in vitro release and transdermal delivery of lamotrigine from…
The drug-in-adhesive (DIA)-type matrix patches of lamotrigine are developed using variable permeation enhancers (oleic acid, PG, lemon oil and aloe vera), and drug in vitro release and its permeation are evaluated.
Lamotrigine has been long used as an anti-epileptic, mood stabilizer, to treat…
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Formulation evaluation of ketoconazole microemulsion‐loaded hydrogel with nigella oil as a…
Onychomycosis is an opportunistic fungal infection often infecting people with compromised immune system. Currently available treatment interventions such as physical, surgical, and chemical‐based approaches are successful in treating the condition, however, are painful and nonpatient complaint.…
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