Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Critical Excipients in Topical and Parenteral Dermatological Formulations: Novel Analytical…
Background & Introduction
Excipients play a crucial role in efficacy, safety and quality of medicinal products. In topical dermatological formulations, often complex excipients of natural or semi-synthetic origin with broad specifications are used (1). In parenteral drug delivery, non-ionic…
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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and…
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to deliver different kinds of therapeutics (e.g., small molecules,…
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Natural product-based excipients for topical green formulations
Abstract
The industry has been paying more attention to the quality of excipients since they play a fundamental role in the efficacy, safety, and acceptability of pharmaceutical products. However, in the case of topical products synthetic compounds have been a concern for consumers, since they can…
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Dual-Drug-Loaded Topical Delivery of Photodynamically Active Lipid-Based Formulation for Combination…
Topical administration of anti-cancer drugs along with photodynamically active molecules is a non-invasive approach, which stands to be a promising modality for treating aggressive cutaneous melanomas with the added advantage of high patient compliance. However, the efficiency of delivering drugs…
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Instantaneous Topical Drug Quantification using a 3D Printed Microfluidic Device and Coherent Raman…
Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30 minutes to hours after application and miss rapid temporal and spatial dynamics, vital to…
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Development, QbD based optimization and in vitro characterization of Diacerein loaded nanostructured…
Abstract
Objective
DCN is a chondro-protective agent which displays inadequate oral bioavailability along with gastrointestinal side effects. It is a choice of drug for treatment of osteoarthritis. Therefore, the objective of this study was to develop and optimize DCN loaded nanostructured lipid…
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Assessing and Predicting Physical Stability of Emulsion-Based Topical Semisolid Products: A Review
The emulsion-based topical semisolid dosage forms present a high degree of complexity due to their microstructures which is apparent from their compositions comprising at least two immiscible liquid phases, often times of high viscosity. These complex microstructures are thermodynamically unstable,…
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The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment…
Chronic wounds affect millions of people globally. This number is set to rise with the increasing incidence of antimicrobial-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which impair the healing of chronic wounds. Lacticin 3147 is a two-peptide chain…
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Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin…
l-ascorbic acid (Vitamin C, VC)is the most abundant antioxidant in human skin. But its poor penetration into the skin and unstability limit the application. The aim of the study was to promote the topical skin permeation and retention of VC, increase the stability as well as effectiveness by a novel…
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Engineered Lipid Excellence Quality & Regulatory – IOI Oleo
See the brochure by IOI Oleo Pharma about their Quality & Regulatory:
EXCIPIENTS & ACTIVE PHARMACEUTICAL
INGREDIENTS - MADE IN GERMANY
Founded in 1905, IOI Oleo’s manufacturing site in Witten has been engaged since the beginning of the 1950s in the manufacturing of…
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