Topical excipients play a crucial role in the formulation of pharmaceutical products intended for external use, such as creams, ointments, gels, and transdermal patches. These excipients serve various purposes, including enhancing drug solubility, ensuring stability, improving drug release, and providing desirable sensory properties.
Pharma Excipients
Topical Excipient
Ionic Liquids Assisted Topical Drug Delivery for Permeation Enhancement: Formulation Strategies,…
Topical drug delivery provides several benefits over other conventional routes by providing localizing therapeutic effects and also avoids the gastrointestinal tract circumventing the first-pass metabolism and enzymatic drug degradation. Being painless, the topical route also prevents the…
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Topical Administration of Drugs Incorporated in Carriers Containing Phospholipid Soft Vesicles for…
This review focuses on the improved topical treatment of various medical skin conditions by the use of drugs delivered from carriers containing phospholipid soft vesicles. Topical drug delivery has many advantages over other ways of administration, having increased patient compliance, avoiding the…
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API-polymer interactions in Sepineo P600 based topical gel formulation – impact on rheology
In the present study, topical gel and emulsion gel were formulated using Acrylamide/ Sodium Acryloyldimethyl taurate copolymer (Sepineo P600) as a gelling agent, and their rheological attributes and physical stability were evaluated upon incorporation of API. Lidocaine, a free base drug (pKa 7.92)…
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Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail…
This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1)…
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DoE Based Formulation Development and Characterization of Topical Nanoemulgel of Diacerein: In-Vitro…
Diacerein (DCN) is the class II rhein derivative with low oral bioavailability, although it has good anti-osteoarthritic action. Because of the potential to induce adverse effects when taken orally, the current study focused on producing a topical nanoemulgel formulation based on the 32 Box-Behnken…
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How to improve topical formulations of poorly-water soluble APIs
Solubility of an Active Pharmaceutical Ingredient (API) in the dosage form is a key parameter in topical formulation. Poor solubility can negatively impact the API drug load, its stability in the dosage form as well as its skin permeation behavior.
Polar solvents such as PEG-400, diethylene…
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In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac…
Topical microemulsion (ME) might provide a novel and advanced transdermal delivery system due to the enhances of drug solubility and permeability across the stratum corneum. Foams are topical delivery systems that have excellent patient compliance, acceptability, and preference. Therefore, this…
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Nanocarrier-based dermopharmaceutical formulations for the topical management of atopic dermatitis
Atopic dermatitis (AD) is a chronic disease that affects the skin, and that is characterized by highly itchy inflammation, frequent eczematous lesions, and a fluctuating course. The current treatment consists of a multi-stage approach that aims to establish persistent disease control towards the…
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Formulation and characterization of curcumin nanoparticles for skin cancer treatment
Curcumin possesses remarkable chemotherapeutic activity owing to its anti-inflammatory and anti-oxidant properties. Purpose of the research work was to prepare curcumin-loaded nanoparticles of Eudragit E 100 for topical skin applications through a simple, cost-effective method of nanoprecipitation.…
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Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and…
Nanocapsules can be equated to other nanovesicular systems in which a drug is entrapped in a void containing liquid core surrounded by a coat. The objective of the present study was to investigate the potential of polymeric and lipid nanocapsules (LNCs) as innovative carrier systems for miconazole…
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