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TPGS
Comparison of two self-nanoemulsifying drug delivery systems using different solidification…
In this study, we aimed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) and a solid self-nanoemulsifying granule system (S-SNEGS) to enhance the solubility and oral bioavailability of celecoxib. This process involved the preparation of a liquid SNEDDS (L-SNEDDS) and its…
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Dual drug-loaded polymeric mixed micelles for ovarian cancer: Approach to enhanced therapeutic…
Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing a dual drug-loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX), encapsulated in a novel carrier matrix of D-tocopheryl polyethylene…
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Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality…
Abstract
Purpose
The study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the carrier and vitamin E TPGS as the surfactant to enhance solubility and dissolution, and to utilize in silico Physiologically Based Biopharmaceutics…
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Self Emulsifying Delivery System of Cissus quadrangularis: Evidence of Enhanced Efficacy and…
Treatment therapies used to manage osteoporosis are associated with severe side effects. So worldwide herbs are widely studied to develop alternative safe & effective treatments. Cissus quadrangularis (CQ) has a significant role in bone health and fracture healing. It is documented that its…
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Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the…
The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the…
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Enhancing breast cancer treatment: Comprehensive study of gefitinib-loaded poloxamer 407/TPGS mixed…
Abstract
Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental process in cell death, are the B-cell lymphoma 2 (Bcl-2) family proteins,…
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Formulation Development, Characterization, and Evaluation of Bedaquiline Fumarate -Soluplus® -Solid…
Bedaquiline fumarate (BQF) is classified as a BCS class II drug and has poor water solubility and dissolution rate, which ultimately compromises bioavailability. The objective of this study is to improve the biopharmaceutical properties of BQF through a solid dispersion system by using Soluplus®.…
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A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric…
Abstract
TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability. However, micelles formulations are generally characterized by low…
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Amorphous – state Characterization and Dissolution Behaviour of Efavirenz – Tocopheryl…
ABSTRACT
The aim of the present investigation was to enhance the aqueous solubility and dissolution rate of a poorly soluble drug, efavirenz, by preparation of solid dispersions with tocopheryl polyethylene glycol succinate (TPGS)-1000, a non-ionic surfactant. Phase solubility studies suggested…
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Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro…
Abstract
Background
Nanocrystals can be produced as a dry powder for inhalation (DPIs) to deliver high doses of drug to the lungs, owing to their high payload and stability to the shear stress of aerosolization force. Furthermore, lipid-coated nanocrystals can be formulated to improve the drug…
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