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TPGS
In vivo evaluation of a novel zero order drug releasing transdermal system of rotigotine
Background: Rotigotine is a new non-ergolinic dopamine agonist used in the treatment of Parkinson's disorder and restless legs syndrome. It has extensive pre-systemic metabolism and administration of rotigotine through transdermal route is the best way to avoid pre-systemic metabolism and thereby to…
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Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates…
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of…
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Preparation of Silymarin–quercetin Loaded Nanoparticles by Spontaneous Emulsification Solvent…
Silymarin, a flavonolignan, derived from Silybum marianum, family Asteraceae has long been used as a hepatoprotective remedy. Silymarin has cytoprotective activities due to its antioxidant property and free radical scavenging activity. The pharmacokinetic studies of past three decades revealed that…
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Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile…
Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed…
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Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate…
Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low bioavailability. D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) is approved as a safe pharmaceutical adjuvant with marked antioxidant and anti-inflammatory…
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Cilostazol Solubilization and Stabilization Using a Polymer-Free Solid Dispersion System
The development of pH-independent drugs is difficult because it involves improvements in their solubility and dissolution (%) in solubilizer. In the present study, the pH-independent cilostazol (CLT) was formulated for enhanced solubility and dissolution (%) and for maintaining stability with…
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Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated…
Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorly-water soluble drugs. While increasing the drug load through thermally-induced supersaturation resulted in enhanced in vivo…
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PMC Isochem To accelerate Polyamino acids Business as part of ISODEL® Drug Delivery offer, a unique…
Press release - Contact: Patti Griggs 856-533-1870
PMC Isochem announces today that it is accelerating the strategic development and manufacture of polyamino acids (PAA) as functional excipients used in complex formulations and drug delivery solutions. Based on its own internal resources and…
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Poloxamine/D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles and gels: Morphology,…
The combination of polymeric surfactants with different features into mixed micelles give access to properties that may be superior to the single-component micelles. In this work, we investigated synergistic effects in mixtures of D-α-Tocopheryl polyethylene glycol succinate (TPGS) with poloxamines…
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Nanocarriers based on vitamin E-TPGS: Design principle and molecular insights into improving the…
α-Tocopheryl polyethylene glycol succinate (Vitamin E-TPGS or TPGS) is a nonionic amphiphile synthesized by the esterification of vitamin E succinate. It has been categorized as a safe excipient by US-FDA and EMA. Like other polyethylene glycol (PEG) condensates, TPGS spontaneously forms kinetically…
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