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TPGS
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-loaded…
Abstract
In this study, a polymer-stabilized nanoemulsion (PNE) was developed to improve the inflammatory and analgesic activities of diclofenac (DA). DA-PNEs were prepared from sesame oil and poloxamer 188 (P188), polysorbate 80, and span 80 as emulsifiers and optimized by a systematic…
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Development of a Bilayer Tablet by Fused Deposition Modeling as a Sustained-Release Drug Delivery…
Three-dimensional printing by fused deposition modeling (FDM) coupled with hot-melt extrusion (HME) is a point of convergence of research efforts directed toward the development of personalized dosage forms. In addition to the customization in terms of shapes, sizes, or delivered drug doses, the…
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Formulation of Silymarin-β Cyclodextrin-TPGS Inclusion Complex: Physicochemical Characterization,…
Abstract
Silymarin (SIL) is a poorly water-soluble flavonoid reported for different pharmacological properties. Its therapeutic applications are limited due to poor water solubility. In this study, the solubility of silymarin has been enhanced by preparing freeze-dried binary and ternary complexes…
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Innovative Design of Targeted Nanoparticles: Polymer–Drug Conjugates for Enhanced Cancer Therapy
Abstract
Polymer–drug conjugates (PDCs) have shown great promise in enhancing the efficacy and safety of cancer therapy. These conjugates combine the advantageous properties of both polymers and drugs, leading to improved pharmacokinetics, controlled drug release, and targeted delivery to tumor…
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Loratadine oral bioavailability enhancement via solid dispersion loaded oro-dispersible films:…
Loratadine (LRD) belongs to second-generation tricyclic H1 antihistamine class, known for its non-sedating properties in allergic reactions. H1 antihistamines avoid and block the responses to allergens or histamine in nose and conjunctivae, thereby abolishing itching, congestion and…
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Polymeric micelles for cutaneous delivery of the hedgehog pathway inhibitor TAK-441: formulation…
TAK-441 is a potent inhibitor of the hedgehog pathway (IC50 4.4 nM) developed for the treatment of basal cell carcinoma that is active against the vismodegib-resistant Smoothened receptor D473H mutant. The objective of this study was to develop a micelle-based formulation of TAK-441 using…
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Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: design,…
While inhalable nanoparticle-based dry powders have demonstrated promising potential as next-generation respiratory medicines, erratic particle redispersibility, and poor manufacturing reproducibility remain major hurdles hindering their translation from bench to bedside. We developed a one-step…
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Lipid based formulations as supersaturating oral delivery systems: from current to future industrial…
Lipid-based formulations, in particular supersaturated lipid-based formulations, are important delivery approaches when formulating challenging compounds, as especially low water-soluble compounds profit from delivery in a pre-dissolved state. In this article, the classification of lipid-based…
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Highly Concentrated Emulsions Containing High Loads of Pterostilbene
Abstract
Pterostilbene is a highly researched molecule due to its bioactivity. However, its hydrophobicity limits its application. For this reason, researchers have sought to encapsulate pterostilbene (namely, in oil-in-water emulsion) to increase its availability. Studies are lacking when it comes…
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Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid…
Solid lipid-based formulations (sLBFs) have the potential to increase the oral bioavailability of drugs with poor solubility in water, while counteracting some of the disadvantages of liquid LBFs. The most common experimental set-up to study the performance of LBFs in vitro is the lipolysis assay,…
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