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TPGS
Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid…
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active pharmaceutical ingredient (API) and small molecule excipients. The properties of these substances make them novel and a very demanding aspect of pharmaceutical research because they improve solubility, physical…
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Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug…
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TPGS Functionalized Carriers: An Emerging Approach for Pulmonary Drug Delivery – Book chapter
Tocophersolan (D-α-tocopheryl polyethylene glycol succinate or TPGS) is a non-ionic surfactant fabricated by esterifying Vitamin E succinate with polyethylene glycol. Owing to its amphipathic nature and unique physicochemical attributes, TPGS offers multiple advantages in drug delivery, such as…
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Engineering artesunate-loaded micelles using spray drying for pulmonary drug delivery
Novel d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles containing the anti-cancer drug artesunate (ART) were developed in a dry powder form for inhalation for the treatment of lung cancer. Targeted delivery to the lungs via inhalation presents a challenge, and the current study…
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Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye…
Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world. Therefore, it is pivotal to develop more sophisticated,…
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Development and evaluation of polymeric mixed micelles prepared using Hot-melt extrusion for…
The poor aqueous solubility is a well-recognized restriction for the clinical application of many drug molecules. Micelles delivery system provides a promising strategy for the solubility enhancement of hydrophobic drugs. This study developed and evaluated different polymeric mixed micelles prepared…
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Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
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Binary Polymeric Surfactant Mixtures for the Development of Novel Loteprednol Etabonate Nanomicellar…
The treatment of several ocular inflammatory conditions affecting different areas of the ocular globe involves the administration of topical ophthalmic formulations containing corticosteroids. This research was aimed at evaluating the solubilising efficacy of 5.0% w/w of different binary mixtures of…
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Development and evaluation of niacinamide transdermal formulation by artificial membrane…
Despite many efforts to improve the transdermal permeability of drugs, most of them are blocked by the skin barrier. Niacinamide (NAC) is a Biopharmaceutics Classification System class I drug with high aqueous solubility and intestinal permeability. Due to the high solubility and intestinal…
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Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal…
ABSTRACT
Objectives
Novel D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified lipid nanocapsules (LNC) were prepared with the aim of improving the effectiveness of simvastatin (SIM) in hepatocellular carcinoma (HCC). The present study, therefore, sought to investigate the…
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