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Transdermal
Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes
The poor aqueous solubility of many approved drugs and most new chemical entities poses a challenge to drug delivery scientists working in academic and industrial labs. Despite the high pharmacological activity these drugs may have, their limited water solubility leads to poor absorption and…
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Investigation of the effect of polymers on dermal foam properties using the QbD approach
Dermal foams are promising drug delivery systems due to their many advantages and ease of application. Foams are also considered a novelty in the field of dermatology. In particular, they are beneficial for the treatment of skin conditions where patients have highly inflamed, swollen, infected and…
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The Transdermal Delivery of Therapeutic Cannabinoids
Recently, several studies have indicated an increased interest in the scientific community regarding the application of Cannabis sativa plants, and their extracts, for medicinal purposes. This plant of enormous medicinal potential has been legalised in an increasing number of countries globally. Due…
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Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC…
The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective…
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Transdermal formulations and strategies for the treatment of osteoporosis
Osteoporosis is a silent and growing disease that constitutes a major health issue, due to its association with an elevated risk of fractures, morbidity, mortality, and re-hospitalization, along with the big financial burden involved. Drugs used in the treatment of this condition are administered…
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Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for…
“On demand” hormonal female-controlled pericoital contraception is one strategy which could be used to minimize the impact of unintended pregnancy. Nestorone (NES) is a potent contraceptive, with relatively few side effects in comparison with other contraceptives. NES presents an attractive option…
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Progress in the transdermal delivery of antimigraine drugs
Most antimigraine drugs are taken orally but the oral route of drug administration has several limitations including pre-systemic metabolism which leads to low bioavailability. Transdermal route provides an alternative method of drug delivery capable of circumventing certain limitations of oral drug…
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Trilayer microneedle array assisted transdermal and intradermal delivery of dexamethasone
Dexamethasone is a synthesised glucocorticoid that is widely used in the treatment of various inflammatory skin conditions. Novel trilayer dissolving microneedle arrays were manufactured to assist dexamethasone delivery via the skin. Both transdermal delivery and intradermal delivery of…
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PharmaTher enters into Process Development Agreement with LTS for Ketamine Microneedle Patch
TORONTO/ANDERNACH, December 20, 2021 — PharmaTher Holdings Ltd. (“PharmaTher”) (OTCQB: PHRRF) (CSE: PHRM), a clinical-stage psychedelics biotech company, and LTS LOHMANN Therapie-Systeme AG (“LTS”), a leading pharmaceutical technology company, today announced they have entered into a process…
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Design and optimization of process parameters of polyvinyl alcohol-graft-lactic acid films for…
The objective was to apply a simplex lattice design to determine the properties of polyvinyl alcohol-graft-lactic acid (PVA-g-LA) with different values for two independent variables: curing time (X1) and LA ratio (X2). Each independent variable was varied among three levels: –1, 0, and +1. Three…
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