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Transdermal
Preparation, optimization and evaluation of transdermal therapeutic system of celecoxib to treat…
The purpose of present study was to prepare transdermal therapeutic system that could enhance dissolution of poorly aqueous soluble drug Celecoxib and thus increase its skin permeation. Solubility studies screened triacetin as oil, cremophor RH 40 as surfactant and Polyethylene Glycol 400 as…
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The technology of transdermal delivery nanosystems: from design and development to preclinical…
Transdermal administration has gained much attention due to the remarkable advantages such as patient compliance, drug escape from first-pass elimination, favorable pharmacokinetic profile and prolonged release properties. However, the major limitation of these systems is the limited skin…
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Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity
Vaccination is an essential public health measure for infectious disease prevention. The exposure of the immune system to vaccine formulations with the appropriate kinetics is critical for inducing protective immunity. In this work, faceted microneedle arrays were designed and fabricated utilizing a…
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Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained…
Fungal infections affect millions of people globally and are often unreceptive to conventional topical or oral preparations because of low drug bioavailability at the infection site, lack of sustained therapeutic effect, and the development of drug resistance. Amphotericin B (AmB) is one of the most…
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In vivo evaluation of a novel zero order drug releasing transdermal system of rotigotine
Background: Rotigotine is a new non-ergolinic dopamine agonist used in the treatment of Parkinson's disorder and restless legs syndrome. It has extensive pre-systemic metabolism and administration of rotigotine through transdermal route is the best way to avoid pre-systemic metabolism and thereby to…
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Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification…
Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H1-antihistaminic activity…
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SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from…
The value proposition for formulation scientists is:
A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
A texture optimal for patient compliance…
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Exploration of a transdermal nanoemulgel as an alternative therapy for postmenopausal osteoporosis
The study investigated the ability of a transdermal nanoemulgel formulation to enhance the bioavailability and anti-osteoporotic efficacy of raloxifene hydrochloride (RH) using recent techniques such as micro-CT, SEM-EDX analysis. The ex-vivo permeation, histopathology, SEM, DSC and CLSM studies…
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Polymeric microneedles for transdermal delivery of nanoparticles: Frontiers of formulation,…
With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes. Among the various types of MNs, polymeric microneedles (PMNs)…
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Molecular Dynamics Simulations to Elucidate Translocation and Permeation of Active from Lipid…
One of the most realistic approaches that could deliver actives (pharmaceuticals/cosmetics) deep into skin layer is encapsulation into nanoparticles (NP). Nonetheless, molecular-level understanding into the mechanism of active delivery from NP to skin has scarcely been studied, compared to their…
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