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Transdermal
Accelerating transdermal delivery of insulin by ginsenoside nanoparticles with unique permeability
Diabetes is a metabolic disease caused by insufficient insulin secretion, action or resistance, in which insulin plays an irreplaceable role in the its treatment. However, traditional administration of insulin requires continuous subcutaneous injections, which is accompanied by inevitable pain,…
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3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of…
A 3D printed assembly of hollow microneedles (HMNs) array, conjoined with a reservoir void, was designed and additively manufactured using stereolithography (SLA) technology utilizing a proprietary class-I resin. The HMNs array was utilized for transdermal delivery of high molecular weight …
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Topical Nanoemulgel for the Treatment of Skin Cancer: Proof-of-Technology
The present study is a mechanistic validation of ‘proof-of-technology’ for the effective topical delivery of chrysin nanoemulgel for localized, efficient treatment of melanoma-affected skin.
Background: Currently available treatments for skin cancer are inefficient due to systemic side effects…
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Development of ketorolac tromethamine loaded microemulsion for topical delivery using D-optimal…
Aim of the present study was to evaluate the potential of microemulsions for the transdermal delivery of ketorolac tromethamine. The pseudo ternary phase diagram, 3 D Optimal mixture design was used to develop the microemulsion of desired properties. Seventeen trial runs were executed by using three…
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Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug…
Biodegradable polymeric microneedle arrays (BPMNAs) could be explored as potential devices for transdermal drug delivery, which can provide a painless and safe drug delivery method. BPMNAs could also provide high drug-loading capacity and prolonged drug delivery once integrated with a drug…
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Transdermal drug delivery systems for fighting common viral infectious diseases
Transdermal drug delivery systems (TDDS) have many advantages and represent an excellent alternative to oral delivery and hypodermic injections. TDDS are more convenient and less invasive tools for disease and viral infection treatment, prevention, detection, and surveillance. The emerging…
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Delivering therapeutic cannabinoids via skin: Current state and future perspectives
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over…
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Formulation and evaluation of transdermal nanogel for delivery of artemether
Artemether (ART) is second to artesunate in being the most widely used derivatives of artemisinin in combination therapy of malaria. Nanostructured lipid carrier (NLC) formulations were prepared following our previous report using optimized ART concentration of 0.25 g dissolved in 5% w/v mixture of…
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Microneedle for transdermal drug delivery: current trends and fabrication
Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and…
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Nanoemulsion-based patch for the dermal delivery of ascorbic acid
Photo-aging is caused mainly by sun radiations, which consist mainly of the ultraviolet radiation (UVA and UVB). Ascorbic acid (AA) has been widely used in the cosmetic field as an anti-wrinkle, anti-pigmentary, and antioxidant agents, however, its cosmetic application is limited due to its poor…
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