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Transdermal
Transdermal delivery and exploration of preclinical anti-rheumatoid efficacy of pirfenidone embedded…
To avoid adverse effects associated with non-site-specific delivery and target major signaling pathways responsible for the inflammation in rheumatoid arthritis, the current study aims to formulate and evaluate the transdermally administered potential of pirfenidone nanoemulgel in rheumatoid…
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Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery
A high-payload ascorbyl palmitate (AP) nanosuspension (NS) was designed to improve skin delivery following topical application. The AP-loaded NS systems were prepared using the bead-milling technique, and softly thickened into NS-loaded gel (NS-G) using hydrophilic polymers. The optimized NS-G…
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Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the…
Abstract
Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these…
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Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation
Abstract
Acyclovir (ACV) is an antiviral drug that is primarily used to treat herpes zoster virus (HSV) infections. HSV infections in deeper regions of the skin, i.e., nerve junctions, and appeared as a red spot on the upper part of the skin. The objective of the research is to formulate and…
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Preparation, optimization and evaluation of Osthole transdermal therapeutic system
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and…
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Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery…
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle has sharp tips and short length, which overcome patients’ pain and improve transdermal efficiency but has low mechanical strength and drug loading…
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Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update…
Abstract
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues.…
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Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs:…
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, with drawbacks such as pain and needle waste. To overcome these limitations, microneedle technology is…
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Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and…
Abstract
This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of high shear homogenization and ultrasonication methods. The…
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Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no…
Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment, we show visual evidence indicating that detachable dissolvable microneedles (DDMN) can deposit cargo into the dermis…
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