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Transdermal
Amorphization of Drugs for Transdermal Delivery -a Recent Update
Amorphous solid dispersion is a popular formulation approach for orally administered poorly water-soluble drugs, especially for BCS class II. But oral delivery could not be an automatic choice for some drugs with high first-pass metabolism susceptibility. In such cases, transdermal delivery is…
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Superiority of Microemulsion-based Hydrogel for Non-Steroidal Anti-Inflammatory Drug Transdermal…
Non-steroidal anti-inflammatory drugs (NSAIDs) represent the foundation of pain management caused by inflammatory disorders. Nevertheless, their oral administration induces several side effects exemplified by gastric ulceration, thus, delivering NSAIDs via the skin has become an attractive…
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Nanostructured lipid carrier based dermal gel of cyclosporine for atopic dermatitis-in vitro and in…
Cyclosporine is a gold treatment standard for the treatment of atopic dermatitis. Patients demand extended therapy without adverse effects as atopic dermatitis is a chronic condition. The objective of the study was to formulate and evaluate nanostructured lipid carriers (NLC) based dermal gel of…
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Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil…
Abstract
Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by…
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In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac…
Topical microemulsion (ME) might provide a novel and advanced transdermal delivery system due to the enhances of drug solubility and permeability across the stratum corneum. Foams are topical delivery systems that have excellent patient compliance, acceptability, and preference. Therefore, this…
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Formulation and Evaluation of Transdermal Gel Containing Tacrolimus-Loaded Spanlastics: In Vitro, Ex…
Our goal was to prepare Span 60-based elastic nanovesicles (spanlastics (SPLs)) of tacrolimus (TCR) using the adapted ethanol injection method, characterize them, and evaluate their ability to improve the transdermal permeation of the active substance. The impact of two different concentrations of…
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Microemulsions and Nanoemulsions in Skin Drug Delivery
Microemulsions and nanoemulsions are lipid-based pharmaceutical systems with a high potential to increase the permeation of drugs through the skin. Although being isotropic dispersions of two nonmiscible liquids (oil and water), significant differences are encountered between microemulsions and…
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Pain management with transdermal drug administration: A review
Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug retention time.
The transdermal route, a…
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Effect of zeta potential of innovative lipid nanocapsules on triamcinolone transdermal delivery
Two pegylated lipid nanocapsules for triamcinolone transdermal delivery were designed. Both present a size close to 50 nm and a single monomodal distribution in particle size (PI < 0.2), with a zeta potential of − 20 ± 2 and + 18 ± 1, respectively. The triamcinolone encapsulation efficacy varied…
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Nanocarriers for promoting skin delivery of therapeutic agents
Compared to oral and injectable administration, a dermal and transdermal drug delivery system that can deliver therapeutic molecules to desired target sites with noninvasive, low toxicity, and convenient self-application is a unique method with high potential and excellent prospects. However, the…
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