Pharma Excipients
Viscocity Agent
Excipient combinations to manage protein viscosity for highly concentrated formulations
Purpose: When delivered via the subcutaneous route of application the volume of a drug is restricted to approx. 2 mL. For therapeutic proteins, such as mAbs or plasma proteins, this restriction requires the use of high protein concentrations. As can be seen by Figure 1 some proteins begin to become…
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Effect of Poly(trehalose methacrylate) Molecular Weight and Concentration on the Stability and…
Instability to storage and shipping conditions and injection administration remain major challenges in treating chronic conditions with biopharmaceuticals. Herein, formulations of poly(trehalose methacrylate) (pTrMA) are successfully optimized to stabilize insulin without appreciably increasing…
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Bio-Based Polyricinoleate and Polyhydroxystearate: Properties and Evaluation as Viscosity Modifiers…
This paper aims to design bio-based polyester as a viscosity modifier for lubricant properties. Bio-based polyricinoleate (PRic) and its saturated homologous polyhydroxystearate (PHS) have been synthesized from fatty acid methyl esters.
The polycondensation performed in bulk in a one-step…
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Novel Technique for Coating of Fine Particles Using Fluidized Bed and Aerosol Atomizer
Fine particles are widely used in many industrial fields, and there are many techniques applied for these particles, like electroplating, and chemical and physical vapor deposition. However, in the food and pharmaceutical industries, most coating processes conducted with fluidized bed use core…
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Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally…
Orally disintegrating tablets (ODTs) manufactured by freeze-drying, also called oral lyophilizates, are a patient-centred dosage form. They possess ultra-fast disintegration dynamics, have acceptable mechanical strength and have a smooth mouth texture. In this study, polyvinyl alcohol (PVA) was…
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Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical…
Silymarin (SLM) is a hepatoprotective herbal drug characterized by low aqueous solubility and, consequently, low oral bioavailability. The objective of this study was to enhance the physiochemical properties of SLM, through preparation and optimization of lyophilized nanosuspension tablets (LNTs).…
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Case Studies on Lipid Excipients
If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration.
How to obtain sustained release tablets of metformin hydrochloride by direct compression?
The aim was to develop dual SR…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Introduction to pharmaceutical excipients – a video
In this video Chris Moreton gives an interesting insight on pharmaceutical excipients.
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Soluplus solutions as thermothickening materials for topical drug delivery.
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have application topical drug delivery to sites including the…
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