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Vitamin E TPGS
Biological fate and interaction with cytochromes P450 of the nanocarrier material, D-α-tocopheryl…
D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with polyethylene glycol (PEG) 1000. It is approved by the US Food and Drug Administration (FDA) and has found wide application in…
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Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid…
Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by Box-Behnken design (3 factors at three levels BBD). Glyceryl…
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A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery…
The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery systems (SNEDDSs) with a limited number of experiments. The strategic approach was based on first identifying appropriate excipients…
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Tocopherols as antioxidants in lipid-based systems: The combination of chemical and physicochemical…
Lipid oxidation is a major concern in the food, cosmetic, and pharmaceutical sectors. The degradation of unsaturated lipids affects the nutritional, physicochemical, and organoleptic properties of products and can lead to off-flavors and to the formation of potentially harmful oxidation compounds.…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
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Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and…
Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare the inclusion complex using β-Cyclodextrins (β-CDs) as complexing agent and D -α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as ternary substance to…
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Monosaccharide-induced growth and higher order transitions in TPGS micelles
D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a nonionic surfactant with low critical micelle concentration. It usually forms spherical core-shell micelles in aqueous media. In this work, we show that these spherical micelles transform to ellipsoid and cylindrical structures upon…
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Hepatoprotective, antioxidant and anti-inflammatory potentials of Vit-E/C@SeNPs in rats: Synthesis,…
This study aimed to synthesize a nano-structure between selenium, Vit. C, and Vit. E (Vit-E/C@SeNPs) as a promising protective and therapeutic agent for hepatocellular carcinoma. Vit-E/C@SeNPs were characterized using TEM and DLS and its zetapotential was measured to evaluate its stability. DPPH…
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Biologic excipients: Importance of clinical awareness of inactive ingredients
Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential implications of these additive substances merit clinical…
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