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Vitamin E TPGS
Amorphous solid dispersion dry powder for pulmonary drug delivery: Advantages and challenges
Amorphous solid dispersion (ASD) is commonly used in pharmaceutical industry. It has been mainly employed to enhance the oral bioavailability of poorly water-soluble drugs that belong to class II and IV of the biopharmaceutical classification system but has showed promise in other areas of…
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Effect of TPGS surfactant on dissolution sensitivity of a poorly water-soluble drug using high-shear…
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely used in a variety of oral applications to enhance dissolution, solubility, and/or bioavailability of poorly-water soluble drugs. In addition, the use of TPGS could potentially minimize achlorhydric effects typically existing in…
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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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Most recent FDA approval for drugs using Vitamin E TPGS in the formulation
Ubrelvy™ December 2019 and Koselugro™ April 2020 are the most recent FDA approval of drug using Vitamin E TPGS in the formulation.
TPGS properties: Emulsifier - solubilizer of poorly soluble drugs - absorption enhancer - PgP inhibitor - plasticizer for HME - stabilizer of Amorphous Solid…
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Improved oral bioavailability and target delivery of 6-Shogaol via Vitamin E TPGS-modified…
6-Shogaol is one component of ginger, which has been described to possess various health-promoting effects including anticancer, anti-inflammatory, antioxidant and antiatherogenic. However, poor water solubility has limited the aforementioned health benefits and clinical applications of the drug.…
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QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic…
Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to develop the nanostructured lipid carriers (NLC) using glyceryl…
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Central Composite Design-Based Optimization of Lopinavir Vitamin E-TPGS Micelle: In Vitro…
Highlights
• Lopinavir was successfully loaded into Vitamin E-TPGS micelles.
• Micelle were prepared by thin film hydration technique.
• Polymer concentration and rotational speed are key parameters in micelle preparation.
• Aqueous solubility of Lopinavir was enhanced by 2.6…
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Optimization and evaluation of encapsulated brimonidine tartrate-loaded nanoparticles incorporation…
Highlights:
PCL-TPGS nanoparticles of BRT were prepared using nanoprecipitation method.
Drug nanoparticles were incorporated into thermosensitive in situ gel systems which provide sustained release than commercial eye drops.
Optimized gels are non-irritating confirmed by ocular…
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Current update on nanoplatforms as therapeutic and diagnostic tools: a review for the materials used…
In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held of great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on…
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Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human ovarian cancer cells line (A2780s) was treated with both PTX and 4-HPR, there was a synergistic anti-cancer effect demonstrated with a average…
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