Browsing Category
Vitamin E TPGS
Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine
Transdermal drug delivery is an alternative route of administration that offers avoidance of the associated drawbacks of orally and parenterally administered hydrophobics. However, owing to the extremely specific set of physicochemical characteristics required for passive transdermal drug…
Read More...
Read More...
TPGS Functionalized Carriers: An Emerging Approach for Pulmonary Drug Delivery – Book chapter
Tocophersolan (D-α-tocopheryl polyethylene glycol succinate or TPGS) is a non-ionic surfactant fabricated by esterifying Vitamin E succinate with polyethylene glycol. Owing to its amphipathic nature and unique physicochemical attributes, TPGS offers multiple advantages in drug delivery, such as…
Read More...
Read More...
VITAMIN C – Tableting with LUBRITAB® RBW Lubricant
Vitamin C (ascorbic acid) is a popular supplement available over the counter in dosage forms such as tablets, capsules, sprinkles and gummies. From a formulator’s perspective, it can be challenging since it is poorly compressible and is very sensitive to moisture. Because of this, it requires…
Read More...
Read More...
Engineering artesunate-loaded micelles using spray drying for pulmonary drug delivery
Novel d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) micelles containing the anti-cancer drug artesunate (ART) were developed in a dry powder form for inhalation for the treatment of lung cancer. Targeted delivery to the lungs via inhalation presents a challenge, and the current study…
Read More...
Read More...
Development and evaluation of polymeric mixed micelles prepared using Hot-melt extrusion for…
The poor aqueous solubility is a well-recognized restriction for the clinical application of many drug molecules. Micelles delivery system provides a promising strategy for the solubility enhancement of hydrophobic drugs. This study developed and evaluated different polymeric mixed micelles prepared…
Read More...
Read More...
Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
Read More...
Read More...
Binary Polymeric Surfactant Mixtures for the Development of Novel Loteprednol Etabonate Nanomicellar…
The treatment of several ocular inflammatory conditions affecting different areas of the ocular globe involves the administration of topical ophthalmic formulations containing corticosteroids. This research was aimed at evaluating the solubilising efficacy of 5.0% w/w of different binary mixtures of…
Read More...
Read More...
Development and evaluation of niacinamide transdermal formulation by artificial membrane…
Despite many efforts to improve the transdermal permeability of drugs, most of them are blocked by the skin barrier. Niacinamide (NAC) is a Biopharmaceutics Classification System class I drug with high aqueous solubility and intestinal permeability. Due to the high solubility and intestinal…
Read More...
Read More...
Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal…
ABSTRACT
Objectives
Novel D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified lipid nanocapsules (LNC) were prepared with the aim of improving the effectiveness of simvastatin (SIM) in hepatocellular carcinoma (HCC). The present study, therefore, sought to investigate the…
Read More...
Read More...
Transferrin functionalized nanostructured lipid carriers for targeting Rivastigmine and Resveratrol…
The management of Alzheimer's disease (AD) remains challenging owing to its complex pathophysiology and blood-brain barrier (BBB) restrictions. A rationally designed combination drug multi-target strategy has emerged as a promising approach for AD management. Considering the lipophilic nature of BBB…
Read More...
Read More...