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Vitamin E TPGS
Emulsification by vitamin E TPGS or Quillaja extract enhanced absorption of berberine without…
Berberine is widely used for the prevention of cancers and diabetes. However, the absorption rate of berberine is less than 1% in humans. The objective of this research was to determine whether emulsification improves the absorption and affects the metabolism of orally ingested berberine. Twelve…
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Lipid/Clay-Based Solid Dispersion Formulation for Improving the Oral Bioavailability of Curcumin
This study was conducted to develop a lipid/clay-based solid dispersion (LSD) formulation to enhance the dissolution and oral bioavailability of poorly soluble curcumin. Krill oil and aminoclay were used as a lipid and a stabilizer, respectively, and LSD formulations of curcumin were prepared by an…
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Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies,…
Abstract
Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress. For instance, the method of preparing ASDs evolved from…
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An insight on lipid nanoparticles for therapeutic proteins delivery
Therapeutic proteins are well-tolerated bioactive compounds used in different therapies, due to its high specificity and biopotency. Nevertheless, they may also present some physicochemical instability, leading to loss of bioactivity hampering treatments. This can be avoided by its loading into…
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Microencapsulation of curcumin by ionotropic gelation with surfactants: Characterization, release…
The purpose of this work was to encapsulate curcumin in pectin beads by ionotropic gelation method in order to improve its solubility and its bioavailability and to preserve its antioxidant activity in the presence of surfactants (Kolliphor® HS 15, TPGS® and BiPro® BLG). Different beads were…
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Vitamin E TPGS-Poloxamer Nanoparticles Entrapping a Novel PI3Kα Inhibitor Potentiate Its Activity…
N-(2-fluorphenyl)-6-chloro-4-hydroxy-2-quinolone-3-carboxamide (R19) is a newly synthesized phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitor with promising activity against cancer cells. The purpose of this study was to develop a polymeric nanoparticle (NP) formulation for R19 to address its…
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Preparation of Solid Self-Nanoemulsifying Drug Delivery Systems (S-SNEDDS) by Co-Extrusion of Liquid…
The present study focused on a new formulation approach to improving the solubility of drugs with poor aqueous solubility. A hot melt extrusion (HME) process was applied to prepare drug-loaded solid self-nanoemulsifying drug delivery systems (S-SNEDDS) by co-extrusion of liquid SNEDDS (L-SNEDDS) and…
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Development of a safe pediatric liquisolid self-nanoemulsifying system of triclabendazole for the…
Fascioliasis, a common parasitic infection observed in the pediatric patient population, is a leading cause of concern in countries with poor/unhealthy water resources. To treat this condition first line agent such as triclabendazole (TBZ) has been the choice therapy. However, there is a major…
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In vitro profiling of fenofibrate solid dispersion mediated tablet formulation to treat high blood…
Objective:
Fenofibrate (FNF), an anti-hyperlipidemic agent, suffers from poor water solubility (0.000707 mg/ml) and belongs to class II drug as per BCS, shows a slow dissolution rate. The current investigation aimed to fabricate a fast-dissolving tablet of FNF (not available in the commercial…
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PMC Isochem – Your partner for Smart & Innovative Solutions
See in the following a part of the company brochure by PMC Isochem
PMC Isochem offers Drug Delivery solutions, CDMO services and Active Pharmaceutical Ingredients and intermediates:
From development to GMP production of Amphiphilic and hydrophilic polymers for pharmaceutical…
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