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Xanthan Gum
Formulation and evaluation of floating tablet of esomeprazole by using natural gums
Abstract
Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a controlled manner with less drug administration frequency,…
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Design of easily swallowable xerogel pill with enough physical strength through hardening-process…
The xerogel pill has been developed as a novel dosage form with dose-adjusting and swallow-assisting functions by using drop freeze-drying (DFD) technique. It was double-structured small sphere composed of an inner drug core and an outer dried-gel layer, however, had problem of insufficient physical…
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Nano-encapsulation of probiotics: Need and critical considerations to design new non-dairy probiotic…
People worldwide need to improve their health or intention to control diseases more naturally through ingredients incorporated into foods and beverages, called functional foods. Functional foods include probiotic organisms and bioactive compounds incorporated into dairy and fermentable foods, whose…
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In Situ Gelling Nasal Drug Delivery System
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To improve the nasal retention time of in-situ gel with nasal…
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A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric…
Abstract
TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability. However, micelles formulations are generally characterized by low…
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Polymeric Nanohydrogel in Topical Drug Delivery System
Nanohydrogels (NH) are biodegradable polymers that have been extensively studied and utilized for various biomedical applications. Drugs in a topical medication are absorbed via the skin and carried to the intended location, where they are metabolized and eliminated from the body. With a focus on…
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A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents,…
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Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the…
(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets containing metronidazole (167 mg/g).
(2) Methods: The…
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Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery
A high-payload ascorbyl palmitate (AP) nanosuspension (NS) was designed to improve skin delivery following topical application. The AP-loaded NS systems were prepared using the bead-milling technique, and softly thickened into NS-loaded gel (NS-G) using hydrophilic polymers. The optimized NS-G…
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Potentially Harmful Excipients: State of the Art for Oral Liquid Forms Used in Neonatology and…
Abstract
The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly for neonates. Toxicity and efficacy divergences have been…
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